Associate Director, Translational Modeling & Simulation

In this role, you will lead model-informed translational work to accelerate oligonucleotide therapeutics from discovery to clinic. You will partner with multidisciplinary teams to develop PK/PD, QSP, and PBPK/PD models that inform dose selection and development decisions. You’ll shape platform translational modeling strategies and expand adoption through internal collaboration and external partnerships. This hybrid, leadership-focused position blends scientific rigor with strategic mentorship to drive access and impact across programs.

• health benefits
• life and disability benefits
• 401(k) with company contribution and match
• competitive salary
• bonus incentives
• annual equity consideration

• Act as the M&S representative on multiple programs and guide decision-making from design to first-in-human dose.
• Build and apply mechanistic models linking pharmacology, tissue distribution, mechanism of action, and downstream effects.
• Integrate modeling with preclinical in vivo/in vitro studies to support candidate selection and progression to clinic.
• Develop platform disease (QSP) and PBPK/PD models spanning multiple projects and phases.
• Contribute to strategic initiatives such as platform-level translational modeling and new modeling workflows (e.g., agentic AI).
• Promote understanding and adoption of translational modeling across partners and through external collaborations.
• Mentor and contribute to wider platforms within M&S as an Associate Director.

• Ph.D. in biology, bioengineering, pharmaceutical sciences, biophysics, or related field with 7+ years of industry experience.

• Collaborative communication to present modeling results to multidisciplinary teams
• Strategic thinking and mentorship
• Proactive engagement with internal partners and external collaborators
• Expert PK/PD modeling
• QSP modeling
• PBPK/PD modeling