Sr. Principal Software and AI Engineer

When considering candidates, we look for scientific and business professionals who are highly motivated, collaborative, and most importantly, share our passionate interest in fighting cancer.

Principal Software and AI Engineer to serve as the senior technical authority for AI-powered applications across drug development, with a primary focus on protocol generation and clinical trial execution. In this hands-on senior technical leadership role, you will help shape the R&D AI strategy and set technical direction for the engineering team, while building critical components yourself and setting best practices for AI-native development within a disciplined, validated SDLC. You will architect and ship production-grade agentic applications and platforms, set standards for evaluation, observability, and GxP compliance, and raise the bar for engineers through design reviews and mentorship.
Build AI and Agentic Applications: Architect, build, and deploy AI and agentic powered applications that accelerate protocol generation and clinical trial execution, from study design through operational delivery.
Partner with clinicians, medical writers, statisticians, data scientists, clinical operations, and product teams to embed AI into regulated clinical development workflows.
Define scalable, reliable platform architecture for multi-agent orchestration, model and tool integration, and the full LLMOps lifecycle.
Establish best practices for AI-native development, evaluation, testing, observability, and continuous performance monitoring within a validated SDLC.
Ensure Compliance: Uphold GxP, data privacy, security, and responsible AI standards, with traceability, auditability, and human oversight built into every system.
Act as tech lead with full ownership of product development, accountable for technical direction, delivery, and quality from concept through production.
Lead project execution, setting priorities, scope, and timelines for the AI engineering team.
Mentor AI and software engineers through design and code reviews, reference implementations, and hands-on guidance.
Lead cross-functional technical workstreams with clinical, medical writing, biostatistics, and clinical operations partners.
Bachelors with 7+ years, Masters with 5+ years or PhD with 3+ years
Experience:

Software and AI/ML engineering experience, including experience as a tech lead or principal engineer owning large-scale AI products end to end. Experience in the pharmaceutical or life sciences industry is strongly preferred.
Track Record:

Proven success shipping production-grade AI and agentic applications that deliver measurable scientific or business impact, ideally in a regulated environment.
Full-Stack Software Engineering:

A strong software engineer first. Deep backend expertise in Python (preferred) and/or .NET, with a track record of architecting and building enterprise applications end to end across frontend, APIs, databases, and deployment. Hands-on experience with relational, search, and graph data stores such as PostgreSQL, Elasticsearch, and Neo4j. Sound judgment in system design, data modeling, and production operations.
Multi-Agent, AI-Native Applications:

Deep, hands-on experience architecting and shipping multi-agent applications to production, with strong command of agent harness design, context engineering, orchestration, tool integration (including MCP), and human-in-the-loop controls.
Frontier Model Application:

Strong judgment in selecting and applying frontier and open-weight models, using structured outputs, guardrails, and validation to ensure stable, robust model behavior. Experience with fine-tuning or post-training is a plus.
Knowledge Engineering:

Proven ability to design and manage enterprise knowledge architecture, including ontology design, knowledge graphs, and retrieval, to make domain knowledge structured, governed, and usable by AI systems.
Proven ability to build multi-layered evaluation, from expert benchmarks and rule-based checks to human review and model-based grading, backed by production monitoring.
AI-Assisted Development:

Fluency with AI coding tools and practices, applied within a disciplined SDLC with rigorous testing, code review, and CI/CD.
Platform and Infrastructure:

Strong knowledge of LLMOps, secure cloud deployment (AWS, Azure, or GCP), and observability.
Experience with clinical protocol development, study design, or clinical trial operations. Familiarity with ICH M11 structured protocols, CDISC standards, or USDM is a strong plus.
Regulated AI:

Working knowledge of GxP, computer system validation, and emerging regulatory guidance on AI in drug development.
Proven ability to act as tech lead, owning product direction and delivery while mentoring senior engineers.
Strong partnership with clinicians, medical writers, statisticians, and clinical operations, translating complex AI concepts for research, regulatory, and executive audiences.
Deep commitment to data privacy, security, and responsible AI in development and deployment.
Travel:

10%
When we exhibit our values of Patients First, Driving Excellence, Bold Ingenuity and Collaborative Spirit, through our twelve global competencies below, we help get more affordable medicines to more patients around the world.
Analytical Thinking/Data Analysis
Financial Excellence
Actual compensation packages are determined by several factors that are unique to each candidate, including but not limited to job-related skills, depth of experience, certifications, relevant education or training, and specific work location. Please note that the listed range reflects the base salary or hourly range only. Non-Commercial roles are eligible to participate in the annual bonus plan, and Commercial roles are eligible to participate in an incentive compensation plan. stock because all employees are eligible for discretionary equity awards and to voluntarily participate in the Employee Stock Purchase Plan. The Company has a comprehensive benefits package that includes Medical, Dental, Vision, 401(k), FSA/HSA, Life Insurance, Paid Time Off, and Wellness.
BeOne does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, disability, national origin, veteran status or any other basis covered by appropriate law. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans’ Readjustment Assistance Act of 1974, Title I of the Americans with Disabilities Act of 1990, and any other applicable federal, state or local laws, applicants who require reasonable accommodation in the job application process may contact